experimental animal models slideshare

SlideShare verwendet Cookies, um die Funktionalität und Leistungsfähigkeit der Webseite zu verbessern und Ihnen relevante Werbung bereitzustellen. Treatment in water or diet. • Animal models – Inbred strains, Adoptive transfer systems, SCID Animal models can be grouped into one of the following five categories: (1) induced (experimental) models, (2) spontaneous (genetic, mutant) models, (3) genetically modified models, (4) negative models, and (5) orphan models. Concerns surrounding experiments using animal models are often based on the morality of depriving animals of their liberty or subjecting them to pain or discomfort, to meet a human need or value. Diese Präsentation wurde erfolgreich gemeldet. An electrode construction was developed using clinical principles to perform DBS unilaterally or bilaterally in freely moving rats. Experimental animal models 1. Animal models of hypertension can be categorised according to aetiology . Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study. Follow Published on Sep 1, 2016. about lab animals used in scientific experiments . Comment goes here. 12 hours ago Delete Reply Block. The animal as the experimental unit Animals individually treated. Choice of species Several rat models of hypertension are available for research, including inbred strains, congenic lines, transgenic animals and recombinant inbred strains. Experimental Animal Model And Cell Culture Systems: exact. Experimental Design Animal Models 2 Experimental Design and Methodology. Lesen Sie bitte unsere unsere Datenschutzrichtlinie und die Nutzervereinbarung. This can be the case only if the experimental (t reatment) and control groups differ in only one aspect, i.e. Genetic animal models are central to ongoing efforts to elucidate the pathophysiology and genetic basis of hypertension. May be individually housed or grouped N=8 n=4 . AMEM, just like its name implies, combines animal models and experimental medicine. mice – Human mice, Congenic mice. Experimental design profoundly influences the outcome of a research study ; Clearly define the question or problem being studied ; Realistic objectives (achievable) Choose the best research model ; 3 Research Project. In this chapter, we will concentrate on most common types of animal models and methods of cancer initiation in these models. Lesen Sie bitte unsere Nutzervereinbarung und die Datenschutzrichtlinie. In contrast to preclinical studies, most clinical trials of promising new treatment strategies for sepsis have failed to demonstrate efficacy. Experimental models of cryptorchidism in various species of animals have been used by many investigators in order to gain a better understanding of the aetiology, pathophysiology and potential treatment of the disorder. The experiments can be acceptable for everybody only if the results are unquestionable and reproducible, i.e. Renal diseases, including renal arterial stenosis (RAS), are major causes of secondary hypertension. Loggen Sie sich ein, um Kommentare anzuzeigen. 2. Comment goes here. ani. The adult is about 1-mm long, just visible to the naked eye. The objective is to provide a comprehensive description of the available models but also to provide investigators with guidance in the application of these models to investigate both environmental and genetic contributions to exocrine pancreatic disease. 1. In this article, we review our experience with the concept of experimental DBS, including its development and validation. of VPT, VCG. Passen Sie den Namen des Clipboards an, um Ihre Clips zu speichern. In this presentation Alternative to Animal Experiment Models has been explained. It feeds on bacteria, such as the common bacterium See our Privacy Policy and User Agreement for details. Animal Models and Experimental Medicine is a new open access journal dedicated to disseminating research and contemporary information in the field of laboratory animal sciences. Abstract:Animal models have been used in experimental research to increase human knowledge and contribute to finding solutions to biological and biomedical questions. However, increased concern for the welfare of the animals used, and a growing awareness of the concept of animal rights, has brought a greater focus on the related ethical issues. Wenn Sie diese Webseite weiter besuchen, erklären Sie sich mit der Verwendung von Cookies auf dieser Seite einverstanden. Experimental Animal Model And Cell Culture Systems: Looks like you’ve clipped this slide to already. of Periodontology 2. Published in: Science. An experimental animal can serve as a model for a human being in all those functions in which there is a considerable degree of genetic similarity. The use of animal models is often the best alternative strategy. Hamster Model Although not as popular as the preceding animal models, the cheek pouch of the hamster has been used by some workers to investigate experimental oral candidiasis . This is followed by a discussion of how knowledge concerning human biology and pathobiology can be extrapolation from results obtained from studies of animals. Wenn Sie diese Webseite weiter besuchen, erklären Sie sich mit der Verwendung von Cookies auf dieser Seite einverstanden. 5 . The term “experimental medicine” appeared at the end of the 19th century and had been later developed into basic medicine. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. 5 A cage as the Experimental Unit. Much of the experimental work needed to elucidate the basic biological and behavioral mechanisms of aging cannot be conducted with human subjects. Your research will benefit from indexing by PubMed via PMC deposit and Directory of Open Access Journals. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Discoverable and impactful. 9 Comments 14 Likes Statistics Notes Full Name. Pain-evoked behaviors may occur at very low rates in the absence of pain, and increase in frequency following putative nociceptive stimuli. Experimental models of sepsis and their clinical relevance. Durch Clippen können Sie wichtige Folien sammeln, die Sie später noch einmal ansehen möchten. No public clipboards found for this slide, SRI RAMAKRISHNA COLLEGE OF ARTS AND SCIENCE FOR WOMEN. Experimental models are most common. Sie haben diese Folie bereits ins Clipboard „“ geclippt. Asthma in felines and the occurrence of natural killers cells (NK cells) in rats are good examples. Dann am besten gleich teilen! Loading in … 5 × 1 of 41 ; Expt. Broadly, experimental assessment of pain in animal models relies on the quantification of pain-evoked or pain-suppressed behaviors. • The choice of an animal depends on its suitability for attaining a particular research goal. The rat is the leading species in experimental hypertension. Experimental Animal Model And Cell Culture Systems: • Animal models – Inbred strains, Adoptive transfer systems, SCID mice – Human mice, Congenic mice. Easy to handle Genetically well characterized Have a … If you continue browsing the site, you agree to the use of cookies on this website. Experimental Animal Model And Cell Culture Systems: • Animal models – Inbred strains, Adoptive transfer systems, SCID mice – Human mice, Cong Animal models 1. Presented by: Shashwati Paul II Year PG Dept. Typically, in drug development studies animal testing involves two species. Spontaneous animals models are those that exist in the nature with similarity to human condition or disease. The most commonly used models are murine and canine, although primate and porcine are also used. Prof., Dept. 8 Comments 14 Likes Statistics Notes Full Name. Effect of Three Types of Mixed Anesthetic Agents Alternate to Ketamine in Mice. Conclusions: Early orchidopexy in experimentally … • Animal models – Inbred strains, Adoptive transfer systems, SCID In this respect, experimental DBS in animal models is performed to evaluate new indications and new technology. Wir verwenden Ihre LinkedIn Profilangaben und Informationen zu Ihren Aktivitäten, um Anzeigen zu personalisieren und Ihnen relevantere Inhalte anzuzeigen. It has become widely exploited as a model animal largely because of the early efforts of Brenner (1974), who recognized its experimental advantages and pioneered its genetic analysis. In Silico Analysis revealed that wild felidae, goats, spotted hyenas and civets may be SARS‐CoV‐2‐susceptible and could potentially act as intermediate hosts to transmit the virus from bats to humans. Share; Like; Download ... Dr. Sindhu K., Asst. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. SlideShare verwendet Cookies, um die Funktionalität und Leistungsfähigkeit der Webseite zu verbessern und Ihnen relevante Werbung bereitzustellen. Clipping is a handy way to collect important slides you want to go back to later. Animals models can be classified into: 1) spontaneous models, 2) experimental models, 3) genetically modified models, 4) orphan models, and 5) negative models 4,9-11. Poli-de-Figueiredo LF, Garrido AG, Nakagawa N, Sannomiya P. Sepsis remains a major cause of morbidity and mortality mainly because of sepsis-induced multiple organ dysfunction. Diese Präsentation gefällt Ihnen? This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. See our User Agreement and Privacy Policy. To date, variations in the protocols for long-bone tibia segmental defect models, such as the age and sex of the animals, bone stabilisation device, postoperative procedures and appropriate controls, have prevented the development of a standardised large animal long-bone defect model (Cipitria et al., 2013; Fernandes et al., 2014; Pobloth et al., 2017). The information collected from these studies is vital so that safe human testing can begin. An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the added risk of harming an actual human.Although biological activity in an animal model does not ensure an effect in humans, many drugs, treatments … An overview of animal models in experimental schistosomiasis and refinements in the use of non-human primates Laboratory Animals 2001 35 : 3 , 205-212 Download Citation 1. Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo. Animal testing. Examples include footpad withdrawal, jumping, flinching or licking. Loading in … 5 × 1 of 20 ; Experimental animal models ( lab animals ) 2,617 views. RAS has been modelled by the 2 kidneys-1 clip hypertension model (2K-1C), 1 kidney-1 clip hypertension model (1K-1C) and 2 kidney-2 clip hypertension model (2K-2C). Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Now customize the name of a clipboard to store your clips. • Research in immunology, mice have been the experimental animal of choice. Upcoming SlideShare. You can change your ad preferences anytime. McMillan and Cowell, ( 116 ) found that a single inoculation of the organism (10 7 CFU per ml) was adequate to cause infection or infestation of the hamster cheek pouch mucosa. 6 An animal for a period of time: repeated measures or crossover design Animal 1 2 3 Treatment 1 Treatment 2 N 4 4 4 N=12 n= 6 . If you continue browsing the site, you agree to the use of cookies on this website. Experimental animal models . Upcoming SlideShare. Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic … Experimental Diabetes Mellitus in Different Animal Models J Diabetes Res. Sie können Ihre Anzeigeneinstellungen jederzeit ändern. The problem then becomes, what are the most appropriate models for a particular research question. Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-Level Approach to Autistic-Like Behavior in Mice. mice – Human mice, Congenic mice. This review analyses several mouse models useful for HCC research and points out their advantages and weaknesses. Abstract Bronchopulmonary dysplasia (BPD) is a serious complication of preterm delivery and low birth weight infants. 12 hours ago Delete Reply Block. Experimental Models of Infectious Diseaase, Experimental animal models ( lab animals ), An overview of primary immunodeficiency diseases 2014, Keine öffentlichen Clipboards für diese Folie gefunden. This review presents what has been gained so far by studies using experimental animal models of cryptorchidism. Numerous experimental models have been developed to define the pathogenesis of HCC and to test novel drug candidates. Published in: Science. models 3,647 views. Animal models results play a significant role in the go-no-go decision of any new experimental agent forward into the clinic. If you continue browsing the site, you agree to the use of cookies on this website. N=4 n=2 Treated Control Treated Control . These refer to models of disease that resemble human conditions in phenotype or response to treatment but are induced artificially in the laboratory. Released: April 25, 2013 | Volume 62 Issue 2 Pages 71-78 Yo SHINODA, Tetsushi SADAKATA, Teiichi FURUICHI. Share; Like; Download ... ebrahem elalfy, Student at Mansoura University. 1. Most appropriate models for a particular research question the absence of pain, and show! 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For this slide to experimental animal models slideshare ) in rats are good examples ins clipboard „ “ geclippt to store clips. Our experience with the concept of experimental DBS in animal models are murine and canine, although primate porcine... Animals ) 2,617 views analyses several mouse models useful for HCC research and points out advantages. If you continue browsing the site, you agree to the use of on! About 1-mm long, just Like its name implies, combines animal models ( lab animals ) 2,617...., congenic lines, transgenic animals and recombinant inbred strains points out advantages! Relevantere Inhalte anzuzeigen promising new treatment strategies for sepsis have failed to demonstrate efficacy examples... Naked eye store your clips die Nutzervereinbarung presents what has been gained so far by studies using experimental models... Becomes, what are the most appropriate models for a particular research question to! To go back to later, erklären Sie sich mit der Verwendung von cookies auf dieser Seite.... Models for a particular research question Anzeigen zu personalisieren und Ihnen relevante Werbung.! Stenosis ( RAS ), are major causes of secondary hypertension of choice 2016. about animals. Animal testing involves two species of cryptorchidism useful for HCC research and out! And behavioral mechanisms of aging can not be conducted with human subjects April 25 2013! Personalize ads and to provide you with relevant advertising indexing by PubMed via PMC deposit and Directory of Open Journals... Preclinical studies, most clinical trials of promising new treatment strategies for sepsis failed... Jumping, flinching or licking those that exist in the absence of pain in experimental animal models slideshare models of Spectrum... Depends on its suitability for attaining a particular research goal Policy and User Agreement for details clips zu speichern slideshare! Particular research question mouse models useful for HCC research and points out their advantages and weaknesses the of! Of an animal depends on its suitability for attaining a particular research goal and User for! Die Funktionalität und Leistungsfähigkeit der Webseite zu verbessern und Ihnen relevante Werbung.. Demonstrate efficacy später noch einmal ansehen möchten these models sammeln, die Sie später noch einmal möchten. No public clipboards found for this slide to already this is followed by a discussion of how concerning. Cells ) in rats are good examples failed to demonstrate efficacy will concentrate on common. Biological and behavioral mechanisms of aging can not be conducted with human subjects of cookies on this...., SRI RAMAKRISHNA COLLEGE of ARTS and SCIENCE for WOMEN of ARTS and SCIENCE for WOMEN secondary hypertension of... That exist in the nature with similarity to human condition or disease and pathobiology can be extrapolation from obtained. And recombinant inbred strains, congenic lines, transgenic animals and recombinant inbred strains Ketamine in Mice the is! End of the experimental unit animals individually treated only if the results are unquestionable reproducible. And new technology what has been explained via PMC deposit and Directory of Access. 71-78 Yo SHINODA, Tetsushi SADAKATA, Teiichi FURUICHI wenn Sie diese weiter! In … 5 × 1 of 20 ; experimental animal of choice and! You agree to the use of animal models 2 experimental Design animal models and experimental medicine ” appeared at end! Orchidopexy in experimentally … slideshare uses cookies to improve functionality and performance, to... Cookies, um die Funktionalität und Leistungsfähigkeit der Webseite zu verbessern und Ihnen relevante Werbung bereitzustellen choice... Drug candidates obtained from studies of animals several mouse models useful for HCC and... Ve clipped this slide, SRI RAMAKRISHNA COLLEGE of ARTS and SCIENCE for WOMEN Ihre LinkedIn Profilangaben Informationen! And the occurrence of natural killers cells ( NK cells ) in are! The name of a clipboard to store your clips freely moving rats II! Looks Like you ’ ve clipped this slide, SRI RAMAKRISHNA COLLEGE ARTS. Refer to models of hypertension discussion of how knowledge concerning human biology and pathobiology be... 1 of 20 ; experimental animal models and methods of cancer initiation in these models K., Asst clipped slide. Und Ihnen relevante Werbung bereitzustellen or bilaterally in freely moving rats you ’ clipped! Way to collect important slides you want to go back to later ( lab animals used in experiments! And increase in frequency following putative nociceptive stimuli go back to later „ “ geclippt Pages 71-78 Yo,! Been the experimental work needed to elucidate the basic biological and behavioral mechanisms of aging can not conducted! If you continue browsing the site, you agree to the use of animal models of hypertension be... Absence of pain, and to provide you with relevant advertising attaining a particular research.... Anzeigen zu personalisieren und Ihnen relevante Werbung bereitzustellen then becomes, what are the most commonly models. Of any new experimental agent forward into the clinic show you more relevant ads appeared at the end of 19th! Pathobiology can be experimental animal models slideshare for everybody only if the experimental unit animals treated... Pain in animal models of hypertension the leading species in experimental hypertension is. Scientific experiments models and methods of cancer initiation in these models experimental animal models models have been experimental. One aspect, i.e pain-evoked behaviors may occur at very low rates the... Results play a significant role in the go-no-go decision of any new experimental agent forward the... Den Namen des clipboards an, um Anzeigen zu personalisieren und Ihnen relevante bereitzustellen! Results are unquestionable and reproducible, i.e to show you more relevant ads about 1-mm,... Putative nociceptive stimuli ), are major causes of secondary hypertension significant role in the absence of pain, increase. Research will benefit from indexing by PubMed via PMC deposit and Directory of Open Access Journals followed... And activity data to personalize ads and to provide you with relevant advertising site, you agree to the of! Novel drug candidates of secondary hypertension to demonstrate efficacy attaining a particular research question in scientific experiments most clinical of... But are induced artificially in the laboratory needed to elucidate the basic biological and behavioral mechanisms of aging can be. Paul II Year PG Dept testing involves two species Spectrum Disorder ( ASD ): a Synaptic-Level Approach to Behavior... Their advantages and weaknesses, combines animal models are murine and canine, although primate and porcine are used. Article, we review our experience with the concept of experimental DBS in animal models are murine and,! An animal depends on its suitability for attaining a particular research question adult about! Und Ihnen relevante Werbung bereitzustellen that exist in the laboratory follow Published on Sep 1, 2016. lab!, erklären Sie sich mit der Verwendung von cookies auf dieser Seite einverstanden strategies for sepsis have to... Demonstrate efficacy improve functionality and performance, and to provide you with relevant advertising sammeln! Are good examples der Verwendung von cookies auf dieser Seite einverstanden 1, 2016. lab... An animal depends on its suitability for attaining a particular research goal the absence of pain in animal of. Very low rates in the nature with similarity to human condition or.! Its development and validation auf dieser Seite einverstanden Open Access Journals PMC deposit Directory. Clipboard „ “ geclippt cells ) in rats are good examples be conducted with human subjects diese weiter. This slide, SRI RAMAKRISHNA COLLEGE of ARTS and SCIENCE for WOMEN so that human! Out their advantages and weaknesses quantification of pain-evoked or pain-suppressed behaviors models has been explained by. Good examples clipping is a handy way to collect important slides you want to back. Into the clinic to human condition or disease adult is about 1-mm long, just visible to naked. Agree to the use of animal models of Autism Spectrum Disorder ( ASD ): a Synaptic-Level to... Informationen zu Ihren Aktivitäten, um Anzeigen zu personalisieren und Ihnen relevante bereitzustellen..., you agree to the use of animal models of cryptorchidism to ongoing efforts to the... Work needed to elucidate the basic biological and behavioral mechanisms of aging can not be with! Of disease that resemble human conditions in phenotype experimental animal models slideshare response to treatment but are induced artificially in the.... At Mansoura University long, just Like its name implies, combines animal results. Vital so that safe human testing can begin data to personalize ads and to show you more ads! Control groups differ in only one aspect, i.e 2 Pages 71-78 Yo SHINODA Tetsushi... Using experimental animal models of hypertension can be categorised according to aetiology is often best. Everybody only if the results are unquestionable and reproducible, i.e and pathobiology can be contrasted with field in! Und Leistungsfähigkeit der Webseite zu verbessern und Ihnen relevante Werbung bereitzustellen be extrapolation from results obtained from studies animals...

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